Georgia at Alabama and the Texas-Oklahoma rivalry will grab most of the attention Saturday. But several other games could shape the college football season.

Indiana, the defending College Football Playoff champion, plays at Nebraska. USA Today's John Brice said the Hoosiers' soft early schedule leaves questions about how they will handle a Big Ten road game. He expects Indiana to win anyway, pointing to Nebraska quarterback Anthony Colandrea's record of 62 touchdown passes and 31 interceptions across three schools.

No. 16 Missouri hosts Texas A&M. The Tigers are 4-1, but their only long road trip ended in a 31-24 loss at Mississippi State. A 5-1 start would put Missouri in territory it has rarely reached since the Gary Pinkel era, USA Today said. Texas A&M has been one of the season's biggest disappointments.

James Madison, under first-year coach Billy Napier, hosts Georgia Southern. The Dukes scored 34 points against Oregon in the first round of last season's playoff and already beat San Diego State on the road this year.

Other big games include USC against Penn State, UCLA against Oregon and Boise State against Fresno State, CBS Sports and NBC Sports listed.

The headliner kicks off in Tuscaloosa, where No. 2 Georgia meets No. 7 Alabama in what USA Today called a "rain-soaked" trip. The winner could take a big step toward the top seed in the playoff.

Oklahoma also faces pressure in the Red River Rivalry. USA Today said a loss to Texas, the Sooners' fourth in five years, would effectively end any meaningful hopes for their season.

Fans can find TV channels and kickoff times in CBS Sports' weekly viewing guide.

What we know: Saturday's Week 6 matchups and rankings.
What we don't: the results, and how weather in Tuscaloosa will affect play.